ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gria2

Full Name:

glutamate receptor, ionotropic, AMPA2 (alpha 2)

Alias:

GluR-B|Glur-2|Glur2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

3 E3|3 33.6 cM

Physical Location:

80488857-80606712 on NC_000069.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2891 Symbol (Name): GRIA2 (glutamate receptor, ionotropic, AMPA 2)

Ortholog Status:

The human GeneID 2891 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gria2
Fold Change:		1.85
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (16141072)
GO:0016020	membrane	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	IDA (14687553\|17093100)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10340301)
GO:0005267	potassium channel activity	Molecular Function	RCA (16141072)
GO:0005234	extracellular-glutamate-gated ion channel activity	Molecular Function	IDA (14687553)
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0004970	ionotropic glutamate receptor activity	Molecular Function	IDA (14687553)
GO:0006810	transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	RCA (16141072)
GO:0007268	synaptic transmission	Biological Process	IDA (14687553)
GO:0006811	ion transport	Biological Process	IEA