Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:14800
Full Name:glutamate receptor, ionotropic, AMPA2 (alpha 2)
Organism:Mus musculus (Mouse)
Genetic Location:3 E3|3 33.6 cM
Physical Location:80488857-80606712 on NC_000069.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2891    Symbol (Name): GRIA2 (glutamate receptor, ionotropic, AMPA 2)
Ortholog Status:The human GeneID 2891 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gria2
Fold Change:1.85
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001039195.1NP_001034284.1NC_000069.5 range: 80488857..80606712, complement
NM_001083806.1NP_001077275.1NC_000069.5 range: 80488857..80606712, complement
NM_013540.2NP_038568.2NC_000069.5 range: 80488857..80606712, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentRCA (16141072)
GO:0016020membraneCellular ComponentIEA
GO:0005624membrane fractionCellular ComponentIDA (14687553|17093100)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (10340301)
GO:0005267potassium channel activityMolecular FunctionRCA (16141072)
GO:0005234extracellular-glutamate-gated ion channel activityMolecular FunctionIDA (14687553)
GO:0005216ion channel activityMolecular FunctionIEA
GO:0004970ionotropic glutamate receptor activityMolecular FunctionIDA (14687553)
GO:0006810transportBiological ProcessIEA
GO:0006813potassium ion transportBiological ProcessRCA (16141072)
GO:0007268synaptic transmissionBiological ProcessIDA (14687553)
GO:0006811ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:14800