ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hand2

Full Name:

heart and neural crest derivatives expressed transcript 2

Alias:

AI225906|AI661148|Ehand2|Hed|Th2|Thing2|dHAND

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 B2|8 30.0 cM

Physical Location:

59800700-59802660 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9464 Symbol (Name): HAND2 (heart and neural crest derivatives expressed 2)

Ortholog Status:

The human GeneID 9464 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws3/Alcw6	Chronic Alcohol Withdrawal	8		16-43 (cM)	3.5	0.0003	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010402.4	NP_034532.3	NC_000074.5 range: 59800700..59802660

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005667	transcription factor complex	Cellular Component	IDA (15351717)
GO:0030528	transcription regulator activity	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	IPI (10924525)
GO:0046982	protein heterodimerization activity	Molecular Function	IPI (12392994)
GO:0005515	protein binding	Molecular Function	IPI (15351717)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (12392994)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (12392994)
GO:0030154	cell differentiation	Biological Process	IEA
GO:0014032	neural crest cell development	Biological Process	IMP (9671575)
GO:0007512	adult heart development	Biological Process	IMP (9171826)
GO:0007507	heart development	Biological Process	IGI (15576406)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IMP (11784028)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (15351717)
GO:0006350	transcription	Biological Process	IEA
GO:0003007	heart morphogenesis	Biological Process	IMP (11784028)
GO:0001947	heart looping	Biological Process	IMP (9171826)
GO:0001701	in utero embryonic development	Biological Process	IMP (9171826)
GO:0001525	angiogenesis	Biological Process	IEA