ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hbegf

Full Name:

heparin-binding EGF-like growth factor

Alias:

AW047313|DTS|Dtr|HB-EGF|Hegfl|MGC107656

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 B2|18 15.0 cM

Physical Location:

36664585-36675427 on NC_000084.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1839 Symbol (Name): HBEGF (heparin-binding EGF-like growth factor)

Ortholog Status:

The human GeneID 1839 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Dtr
Fold Change:		0.56
Note:		Significantly regulated by ethanol in cortical neurons

Gene Information

Original ID1:		Dtr
Fold Change:		0.62
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010415.1	NP_034545.1	NC_000084.5 range: 36664585..36675427, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005154	epidermal growth factor receptor binding	Molecular Function	IDA (1840698)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0008083	growth factor activity	Molecular Function	IDA (1840698)
GO:0008201	heparin binding	Molecular Function	IDA (1840698)
GO:0035313	wound healing, spreading of epidermal cells	Biological Process	IMP (15923649)
GO:0048661	positive regulation of smooth muscle cell proliferation	Biological Process	IDA (1840698)
GO:0001525	angiogenesis	Biological Process	NAS (15289334)
GO:0008016	regulation of heart contraction	Biological Process	IMP (12621152)
GO:0007173	epidermal growth factor receptor signaling pathway	Biological Process	IDA (12621152)
GO:0001832	blastocyst growth	Biological Process	TAS (10101133)
GO:0051549	positive regulation of keratinocyte migration	Biological Process	IMP (15923649)