ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hmgcl

Full Name:

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

Alias:

AW476067|HL

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 D3|4 65.6 cM

Physical Location:

135502359-135518527 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3155 Symbol (Name): HMGCL (3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria))

Ortholog Status:

The human GeneID 3155 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap3q	Alcohol Preference Drinking	4	75	65-ter (cM)	4.6		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008254.2	NP_032280.2	NC_000070.5 range: 135502359..135518527

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0005743	mitochondrial inner membrane	Cellular Component	IDA (12865426)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004419	hydroxymethylglutaryl-CoA lyase activity	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA