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Gene Information
Gene ID:155
Symbol:ADRB3
Full Name:adrenergic, beta-3-, receptor
Alias:BETA3AR
Organism:Homo sapiens (Human)
Chromosome:8
Genetic Location:8p12-p11.2
Physical Location:37939672-37943340 on NC_000008.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:ADRB3
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
ADRB31Alcoholism
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000025.1NP_000016.1NC_000008.9 range: 37939672..37943340, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043235receptor complexCellular ComponentIDA (15123695)
GO:0005886plasma membraneCellular ComponentTAS (1718744)
GO:0005887integral to plasma membraneCellular ComponentTAS (1718744)
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0042803protein homodimerization activityMolecular FunctionIDA (15123695)
GO:0015052beta3-adrenergic receptor activityMolecular FunctionIMP (9892244)
GO:0051380norepinephrine bindingMolecular FunctionIDA (15123695)
GO:0004872receptor activityMolecular FunctionIEA
GO:0006112energy reserve metabolic processBiological ProcessTAS (1718744)
GO:0043410positive regulation of MAPKKK cascadeBiological ProcessIDA (15123695)
GO:0002032desensitization of G-protein coupled receptor protein signaling pathway by arrestinBiological ProcessIDA (15123695)
GO:0005975carbohydrate metabolic processBiological ProcessTAS (2570461)
GO:0007190activation of adenylate cyclase activityBiological ProcessIDA (15123695)
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerBiological ProcessTAS (1718744)
GO:0007165signal transductionBiological ProcessIEA
GO:0006091generation of precursor metabolites and energyBiological ProcessTAS (2570461)
GO:0006898receptor-mediated endocytosisBiological ProcessIDA (15123695)
Other Database Cross Links
NCBI Entrez Gene:155
HGNC:288
Ensembl:ENSG00000188778
MIM:109691
HPRD:00188
HuGE Navigator:155
dbSNP:ADRB3
GeneCard:ADRB3
AceView:ADRB3