ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CYP3A4

Full Name:

cytochrome P450, family 3, subfamily A, polypeptide 4

Alias:

CP33|CP34|CYP3A|CYP3A3|HLP|MGC126680|NF-25|P450C3|P450PCN1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7q21.1

Physical Location:

99192539-99219743 on NC_000007.12, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CYP3A4

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017460.3	NP_059488.2	NC_000007.12 range: 99192539..99219743, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0009986	cell surface	Cellular Component	IEP (12493773)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005792	microsome	Cellular Component	TAS (3460094)
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	TAS (11726664)
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Molecular Function	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0019825	oxygen binding	Molecular Function	TAS (2492107\|3460094)
GO:0050591	quinine 3-monooxygenase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Molecular Function	IEA
GO:0004497	monooxygenase activity	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0050649	testosterone 6-beta-hydroxylase activity	Molecular Function	IDA (11726664)
GO:0006805	xenobiotic metabolic process	Biological Process	TAS (11726664)
GO:0006629	lipid metabolic process	Biological Process	TAS (2492107)