ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Il3

Full Name:

interleukin 3

Alias:

BPA|Csfmu|HCGF|Il-3|MCGF|PSF

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B1|11 28.5 cM

Physical Location:

54078586-54080780 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3562 Symbol (Name): IL3 (interleukin 3 (colony-stimulating factor, multiple))

Ortholog Status:

The human GeneID 3562 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws4/Alcw3	Chronic Alcohol Withdrawal	11		15-36 (cM)	6.7	2.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010556.4	NP_034686.2	NC_000077.5 range: 54078586..54080780, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	IDA (7690439)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005125	cytokine activity	Molecular Function	IDA (1350248\|7519779\|7736574\|7957045\|10652277\|10872802\|14967141)
GO:0005135	interleukin-3 receptor binding	Molecular Function	IEA
GO:0008083	growth factor activity	Molecular Function	IDA (7957045)
GO:0043066	negative regulation of apoptosis	Biological Process	IDA (14967141)
GO:0045885	positive regulation of survival gene product expression	Biological Process	IDA (7736574\|10652277)
GO:0046330	positive regulation of JNK cascade	Biological Process	IDA (14967141)
GO:0001934	positive regulation of protein amino acid phosphorylation	Biological Process	IDA (14967141)
GO:0046330	positive regulation of JNK cascade	Biological Process	IMP (14967141)
GO:0033028	myeloid cell apoptosis	Biological Process	IDA (9202146)
GO:0019221	cytokine and chemokine mediated signaling pathway	Biological Process	IDA (7519779)
GO:0010468	regulation of gene expression	Biological Process	IDA (9697835)
GO:0008284	positive regulation of cell proliferation	Biological Process	IGI (7690439)
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA (1350248\|7736574\|7957045)
GO:0006955	immune response	Biological Process	IEA
GO:0002763	positive regulation of myeloid leukocyte differentiation	Biological Process	IGI (1375116\|7690439)
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process	IDA (7519779\|10872802)