ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

16331

Symbol:

Inpp5d

Full Name:

inositol polyphosphate-5-phosphatase D

Alias:

AI323613|MGC117680|SHIP|SHIP-1|s-SHIP

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 C5|1 57.0 cM

Physical Location:

89516953-89617076 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3635 Symbol (Name): INPP5D (inositol polyphosphate-5-phosphatase, 145kDa)

Ortholog Status:

The human GeneID 3635 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010566.2	NP_034696.2	NC_000067.5 range: 89516953..89617076

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0004437	inositol or phosphatidylinositol phosphatase activity	Molecular Function	RCA (12466851)
GO:0005515	protein binding	Molecular Function	IPI (11031258)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0045579	positive regulation of B cell differentiation	Biological Process	IMP (9620849\|10704460)
GO:0045621	positive regulation of lymphocyte differentiation	Biological Process	IMP (9620849)
GO:0045648	positive regulation of erythrocyte differentiation	Biological Process	IMP (9620849)
GO:0045656	negative regulation of monocyte differentiation	Biological Process	IMP (9620849)
GO:0045659	negative regulation of neutrophil differentiation	Biological Process	IMP (9620849)
GO:0045671	negative regulation of osteoclast differentiation	Biological Process	IMP (12161749)
GO:0045779	negative regulation of bone resorption	Biological Process	IMP (12161749)
GO:0050777	negative regulation of immune response	Biological Process	IMP (10704460)
GO:0045409	negative regulation of interleukin-6 biosynthetic process	Biological Process	IMP (12161749)
GO:0043065	positive regulation of apoptosis	Biological Process	IMP (12161749)
GO:0006915	apoptosis	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IMP (10704460)
GO:0008340	determination of adult life span	Biological Process	IMP (9620849)
GO:0009968	negative regulation of signal transduction	Biological Process	IMP (9620849\|10704460\|12161749)
GO:0016064	immunoglobulin mediated immune response	Biological Process	IMP (10704460)
GO:0030853	negative regulation of granulocyte differentiation	Biological Process	IMP (9620849)
GO:0030889	negative regulation of B cell proliferation	Biological Process	IMP (10704460)
GO:0050869	negative regulation of B cell activation	Biological Process	IMP (10704460)