ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Irs1

Full Name:

insulin receptor substrate 1

Alias:

G972R|IRS-1

Organism:

Mus musculus (Mouse)

Chromosome:

1

Genetic Location:

1 C5|1 57.0 cM

Physical Location:

82233184-82287990 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010570.4	NP_034700.2	NC_000067.5 range: 82233184..82287990, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005792	microsome	Cellular Component	IDA (12832401)
GO:0005829	cytosol	Cellular Component	EXP (11147812)
GO:0005737	cytoplasm	Cellular Component	IDA (12878164)
GO:0005634	nucleus	Cellular Component	IDA (12878164)
GO:0005515	protein binding	Molecular Function	IPI (11018022)
GO:0005158	insulin receptor binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0019901	protein kinase binding	Molecular Function	IDA (14733908)
GO:0030879	mammary gland development	Biological Process	IGI (17662267)
GO:0030335	positive regulation of cell migration	Biological Process	IGI (17662267)
GO:0030073	insulin secretion	Biological Process	IMP (9062343)
GO:0007165	signal transduction	Biological Process	IEA
GO:0002053	positive regulation of mesenchymal cell proliferation	Biological Process	IGI (17662267)
GO:0043491	protein kinase B signaling cascade	Biological Process	IGI (15249583)

Other Database Cross Links

NCBI Entrez Gene:

MGI:

Ensembl:

ENSMUSG00000022591

dbSNP:

AceView: