ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Itga4

Full Name:

integrin alpha 4

Alias:

CD49D

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 C3|2 46.0 cM

Physical Location:

79095582-79173270 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3676 Symbol (Name): ITGA4 (integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor))

Ortholog Status:

The human GeneID 3676 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Etact1	Alcohol Stimulated Activity	2	51	41-61 (cM)	3.9	2.20E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010576.3	NP_034706.3	NC_000068.6 range: 79095582..79173270

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0009897	external side of plasma membrane	Cellular Component	IDA (8557754)
GO:0008305	integrin complex	Cellular Component	IEA
GO:0001968	fibronectin binding	Molecular Function	IMP (8145052)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0007507	heart development	Biological Process	IMP (12021259)
GO:0007229	integrin-mediated signaling pathway	Biological Process	IEA
GO:0007159	leukocyte adhesion	Biological Process	IMP (8562500)
GO:0007157	heterophilic cell adhesion	Biological Process	IMP (8145052)
GO:0007155	cell adhesion	Biological Process	IMP (12021259)
GO:0001974	blood vessel remodeling	Biological Process	IMP (16529735)
GO:0016477	cell migration	Biological Process	IMP (12021259\|16529735)