ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

AKR1C1

Full Name:

aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

Alias:

2-ALPHA-HSD|20-ALPHA-HSD|C9|DD1|DDH|DDH1|H-37|HAKRC|MBAB|MGC8954

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10p15-p14

Physical Location:

4995453-5010157 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AKR1C1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001353.5	NP_001344.2	NC_000010.9 range: 4995453..5010157

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IDA (8486699)
GO:0004033	aldo-keto reductase activity	Molecular Function	TAS (7789999)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0047006	20-alpha-hydroxysteroid dehydrogenase activity	Molecular Function	IEA
GO:0047042	3-alpha-hydroxysteroid dehydrogenase (B-specific) activity	Molecular Function	IDA (8486699)
GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	Molecular Function	IDA (8486699)
GO:0032052	bile acid binding	Molecular Function	IDA (8486699)
GO:0051260	protein homooligomerization	Biological Process	IDA (8486699)
GO:0042632	cholesterol homeostasis	Biological Process	TAS (8486699)
GO:0030299	cholesterol absorption	Biological Process	TAS (8486699)
GO:0015721	bile acid and bile salt transport	Biological Process	TAS (8486699)
GO:0008206	bile acid metabolic process	Biological Process	IDA (8486699)
GO:0007586	digestion	Biological Process	IDA (8486699)
GO:0006805	xenobiotic metabolic process	Biological Process	NAS (8486699)
GO:0055114	oxidation reduction	Biological Process	IDA (8486699)