ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Jak1

Full Name:

Janus kinase 1

Alias:

AA960307|C130039L05Rik|MGC37919

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 C6|4 46.3 cM

Physical Location:

100824578-100937886 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3716 Symbol (Name): JAK1 (Janus kinase 1 (a protein tyrosine kinase))

Ortholog Status:

The human GeneID 3716 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws2	Chronic Alcohol Withdrawal	4		33-51 (cM)	2.3	0.005	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_146145.2	NP_666257.2	NC_000070.5 range: 100824578..100937886, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12738762\|17855365)
GO:0004718	Janus kinase activity	Molecular Function	IEA
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IDA (10872802)
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0018108	peptidyl-tyrosine phosphorylation	Biological Process	IDA (10872802)
GO:0007243	protein kinase cascade	Biological Process	IDA (8022486)
GO:0007167	enzyme linked receptor protein signaling pathway	Biological Process	IDA (8022486)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0019221	cytokine and chemokine mediated signaling pathway	Biological Process	IDA (8022486)