ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Kif1c

Full Name:

kinesin family member 1C

Alias:

B430105J22Rik|D11Bwg1349e|Ltxs1|MGC28766

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B3

Physical Location:

70516301-70542380 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10749 Symbol (Name): KIF1C (kinesin family member 1C)

Ortholog Status:

The human GeneID 10749 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Kif1c

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Information

Dataset Information

Name:		16783646
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Alcohol preference, acute functional tolerance
Publication:		Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:		Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore4	Alcohol-induced Loss of Righting Reflex	11		36-42 (cM)	6.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_153103.2	NP_694743.2	NC_000077.5 range: 70516301..70542380

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005794	Golgi apparatus	Cellular Component	IDA (11784862)
GO:0005874	microtubule	Cellular Component	IEA
GO:0005875	microtubule associated complex	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003774	motor activity	Molecular Function	IEA
GO:0003777	microtubule motor activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	Biological Process	IDA (11784862)
GO:0007018	microtubule-based movement	Biological Process	IEA