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Gene Information
Gene ID:16562
Full Name:kinesin family member 1C
Organism:Mus musculus (Mouse)
Genetic Location:11 B3
Physical Location:70516301-70542380 on NC_000077.5
Gene Type:protein-coding
Human Ortholog:GeneID: 10749    Symbol (Name): KIF1C (kinesin family member 1C)
Ortholog Status:The human GeneID 10749 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Kif1c
Dataset Information
Tissue:Whole brain
Phenotype:Alcohol preference
Publication:Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.
Gene Information
Original ID1:Kif1c
Fold Change:4.69
P Value:0.002
Note:acute functional tolerance
Dataset Information
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Alcohol preference, acute functional tolerance
Publication:Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Lore4Alcohol-induced Loss of Righting Reflex11 36-42 (cM)6.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_153103.2NP_694743.2NC_000077.5 range: 70516301..70542380
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005794Golgi apparatusCellular ComponentIDA (11784862)
GO:0005874microtubuleCellular ComponentIEA
GO:0005875microtubule associated complexCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0003774motor activityMolecular FunctionIEA
GO:0003777microtubule motor activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0006890retrograde vesicle-mediated transport, Golgi to ERBiological ProcessIDA (11784862)
GO:0007018microtubule-based movementBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:16562