ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sgk3

Full Name:

serum/glucocorticoid regulated kinase 3

Alias:

2510015P22Rik|A330005P07Rik|Cisk|fy|fz

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 A2|1 7.5 cM

Physical Location:

9788210-9892650 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23678 Symbol (Name): SGK3 (serum/glucocorticoid regulated kinase family, member 3)

Ortholog Status:

The human GeneID 23678 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AA982701
Fold Change:		1.9, 1.9, 1.3, 1.6
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0016023	cytoplasmic membrane-bounded vesicle	Cellular Component	IDA (11050396)
GO:0005768	endosome	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0035091	phosphoinositide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (11050396)
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007154	cell communication	Biological Process	IEA
GO:0006916	anti-apoptosis	Biological Process	IDA (11050396)