ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pib5pa

Full Name:

phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A

Alias:

Pipp

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 A1

Physical Location:

3394385-3404823 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 27124 Symbol (Name): PIB5PA (phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A)

Ortholog Status:

The human GeneID 27124 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pib5pa
Fold Change:		0.57
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_172439.2	NP_766027.1	NC_000077.5 range: 3394385..3404823, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000300	peripheral to membrane of membrane fraction	Cellular Component	ISO
GO:0001726	ruffle	Cellular Component	ISS (12536145)
GO:0005737	cytoplasm	Cellular Component	ISS (12536145)
GO:0004437	inositol or phosphatidylinositol phosphatase activity	Molecular Function	RCA (12466851)
GO:0004445	inositol-polyphosphate 5-phosphatase activity	Molecular Function	ISO
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008150	biological_process	Biological Process	ND