ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Akap5

Full Name:

A kinase (PRKA) anchor protein 5

Alias:

AKAP150|Akap79|P150

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

6q24

Physical Location:

98923119-98928504 on NC_005105.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9495 Symbol (Name): AKAP5 (A kinase (PRKA) anchor protein 5)

Ortholog Status:

The human GeneID 9495 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_133515.1	NP_598199.1	NC_005105.2 range: 98923119..98928504

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005515	protein binding	Molecular Function	IPI (12938160)
GO:0005516	calmodulin binding	Molecular Function	IEA
GO:0019901	protein kinase binding	Molecular Function	IDA (2538452)
GO:0006605	protein targeting	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0051493	regulation of cytoskeleton organization and biogenesis	Biological Process	IPI (12938160)