| Gene Information |
| Gene ID: | | 17118 |
| Symbol: | | Marcks |
| Full Name: | | myristoylated alanine rich protein kinase C substrate |
| Alias: | | Macs|PKCSL |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 10 |
| Genetic Location: | | 10 B1|10 22.0 cM |
| Physical Location: | | 36853048-36858731 on NC_000076.5, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 4082 Symbol (Name): MARCKS (myristoylated alanine-rich protein kinase C substrate) |
| Ortholog Status: | | The human GeneID 4082 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Marcks | | Fold Change: | | 1.61 | | Note: | | Significantly regulated by ethanol in cortical neurons |
| | Dataset Information | | Name: | | 17295719 | | Method: | | Microarray | | Tissue: | | Cultured fetal mouse cortical neurons | | Phenotype: | | Ethanol response | | Publication: | | Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed | | Summary: | | By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005737 | cytoplasm | Cellular Component | IDA (15766745) | |
| GO:0005813 | centrosome | Cellular Component | IDA (15766745) | |
| GO:0005856 | cytoskeleton | Cellular Component | IEA | |
| GO:0005938 | cell cortex | Cellular Component | IDA (15766745) | |
| GO:0016020 | membrane | Cellular Component | IDA (12888215) | |
| GO:0042585 | germinal vesicle | Cellular Component | IDA (15766745) | |
| GO:0003779 | actin binding | Molecular Function | IEA | |
| GO:0005516 | calmodulin binding | Molecular Function | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 17118 |
| MGI: | |
| Ensembl: | | ENSMUSG00000069662 |
| dbSNP: | | Marcks |
| AceView: | | Marcks |
