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Gene Information
Gene ID:17118
Full Name:myristoylated alanine rich protein kinase C substrate
Organism:Mus musculus (Mouse)
Genetic Location:10 B1|10 22.0 cM
Physical Location:36853048-36858731 on NC_000076.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4082    Symbol (Name): MARCKS (myristoylated alanine-rich protein kinase C substrate)
Ortholog Status:The human GeneID 4082 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Marcks
Fold Change:1.61
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008538.2NP_032564.1NC_000076.5 range: 36853048..36858731, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (15766745)
GO:0005813centrosomeCellular ComponentIDA (15766745)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005938cell cortexCellular ComponentIDA (15766745)
GO:0016020membraneCellular ComponentIDA (12888215)
GO:0042585germinal vesicleCellular ComponentIDA (15766745)
GO:0003779actin bindingMolecular FunctionIEA
GO:0005516calmodulin bindingMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:17118