ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Maff

Full Name:

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 E1|15 46.0 cM

Physical Location:

79178107-79189505 on NC_000081.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23764 Symbol (Name): MAFF (v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian))

Ortholog Status:

The human GeneID 23764 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AA060508
Fold Change:		NC, NC, 1.9, 1.6
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC
Aaq1/Etacc	Alcohol Acceptance	15	30	15-48 (cM)	3.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010755.3	NP_034885.1	NC_000081.5 range: 79178107..79189505

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0001701	in utero embryonic development	Biological Process	IGI (15087497)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0045604	regulation of epidermal cell differentiation	Biological Process	IGI (15087497)