ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Man2b1

Full Name:

mannosidase 2, alpha B1

Alias:

AW107687|LAMAN

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 C2|8 37.0 cM

Physical Location:

87607167-87622637 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4125 Symbol (Name): MAN2B1 (mannosidase, alpha, class 2B, member 1)

Ortholog Status:

The human GeneID 4125 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Man2b1

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws3/Alcw6	Chronic Alcohol Withdrawal	8		16-43 (cM)	3.5	0.0003	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010764.2	NP_034894.2	NC_000074.5 range: 87607167..87622637

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005764	lysosome	Cellular Component	IEA
GO:0004559	alpha-mannosidase activity	Molecular Function	IDA (9305783\|9355733)
GO:0016798	hydrolase activity, acting on glycosyl bonds	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0015923	mannosidase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0004559	alpha-mannosidase activity	Molecular Function	IMP (10400983)
GO:0008152	metabolic process	Biological Process	IEA
GO:0006013	mannose metabolic process	Biological Process	IMP (10400983)
GO:0006013	mannose metabolic process	Biological Process	IDA (9305783\|9355733)
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0007611	learning and/or memory	Biological Process	IMP (16014715)