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Gene Information
Gene ID:172643
Organism:Caenorhabditis elegans (Worm)
Physical Location:8526752-8529262 on NC_003279.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 55738    Symbol (Name): ARFGAP1 (ADP-ribosylation factor GTPase activating protein 1)
Ortholog Status:The human GeneID 55738 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:K02B12.7
Note:Class II: late induction
Dataset Information
Phenotype:Ethanol response
Publication:Kwon et al. Genomics. (2004) Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. PubMed
Summary:We used in this report the nematode Caenorhabditis elegans as a model system to identify and characterize the genes that are affected by ethanol exposure and to link those genes functionally into an ethanol-induced gene network. By analyzing the expression profiles of all C. elegans ORFs using microarrays, we identified 230 genes affected by ethanol. While the ethanol response of some of the identified genes was significant at early time points, that of the majority was at late time points, indicating that the genes in the latter case might represent the physiological consequence of the ethanol exposure. We further characterized the early response genes that may represent those involved directly in the ethanol response. These genes included many heat shock protein genes, indicating that high concentration of ethanol acts as a strong stress to the animal.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_059909.2NP_492310.1NC_003279.5 range: 8526752..8529262, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0008060ARF GTPase activator activityMolecular FunctionIEA (12520011|12654719)
GO:0008270zinc ion bindingMolecular FunctionIEA (12520011|12654719)
GO:0032312regulation of ARF GTPase activityBiological ProcessIEA (12520011|12654719)
Other Database Cross Links
NCBI Entrez Gene:172643