ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Aff1

Full Name:

AF4/FMR2 family, member 1

Alias:

9630032B01Rik|AW319193|Af4|Mllt2h|Rob

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 E|5 56.0 cM

Physical Location:

104183180-104284340 on NC_000071.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4299 Symbol (Name): AFF1 (AF4/FMR2 family, member 1)

Ortholog Status:

The human GeneID 4299 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI836732
Fold Change:		2.3, 1.5, 1.6, 1.5
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (9365243)
GO:0003700	transcription factor activity	Molecular Function	TAS (11923441)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016563	transcription activator activity	Molecular Function	IDA (9365243)
GO:0006350	transcription	Biological Process	TAS (11923441)
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA (9365243)