ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

vhp-1

Organism:

Caenorhabditis elegans (Worm)

Chromosome:

Physical Location:

5322977-5340217 on NC_003280.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1850 Symbol (Name): DUSP8 (dual specificity phosphatase 8)

Ortholog Status:

The human GeneID 1850 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		F08B1.1
Note:		Class II: late induction

Dataset Information

Name:		15028283
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Kwon et al. Genomics. (2004) Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. PubMed
Summary:		We used in this report the nematode Caenorhabditis elegans as a model system to identify and characterize the genes that are affected by ethanol exposure and to link those genes functionally into an ethanol-induced gene network. By analyzing the expression profiles of all C. elegans ORFs using microarrays, we identified 230 genes affected by ethanol. While the ethanol response of some of the identified genes was significant at early time points, that of the majority was at late time points, indicating that the genes in the latter case might represent the physiological consequence of the ethanol exposure. We further characterized the early response genes that may represent those involved directly in the ethanol response. These genes included many heat shock protein genes, indicating that high concentration of ethanol acts as a strong stress to the animal.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Molecular Function	IEA (12520011\|12654719)
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IEA (12520011\|12654719)
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Molecular Function	IEA (12520011\|12654719)
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IEA (12520011\|12654719)
GO:0040017	positive regulation of locomotion	Biological Process	IMP (12529635)
GO:0040010	positive regulation of growth rate	Biological Process	IMP (16507136)
GO:0016311	dephosphorylation	Biological Process	IEA (12520011\|12654719)
GO:0000188	inactivation of MAPK activity	Biological Process	IGI (15116070)
GO:0006952	defense response	Biological Process	IMP (15256594)
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA (12520011\|12654719)
GO:0002119	nematode larval development	Biological Process	IMP (15116070)
GO:0002009	morphogenesis of an epithelium	Biological Process	IMP (12529635)
GO:0046688	response to copper ion	Biological Process	IGI (15116070)