ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

rab-3

Organism:

Caenorhabditis elegans (Worm)

Chromosome:

Physical Location:

5721729-5727638 on NC_003280.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 115827 Symbol (Name): RAB3C (RAB3C, member RAS oncogene family)

Ortholog Status:

The human GeneID 115827 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		C18A3.6
Note:		Class IV: late repression

Dataset Information

Name:		15028283
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Kwon et al. Genomics. (2004) Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. PubMed
Summary:		We used in this report the nematode Caenorhabditis elegans as a model system to identify and characterize the genes that are affected by ethanol exposure and to link those genes functionally into an ethanol-induced gene network. By analyzing the expression profiles of all C. elegans ORFs using microarrays, we identified 230 genes affected by ethanol. While the ethanol response of some of the identified genes was significant at early time points, that of the majority was at late time points, indicating that the genes in the latter case might represent the physiological consequence of the ethanol exposure. We further characterized the early response genes that may represent those involved directly in the ethanol response. These genes included many heat shock protein genes, indicating that high concentration of ethanol acts as a strong stress to the animal.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA (12520011\|12654719)
GO:0003924	GTPase activity	Molecular Function	IEA (12520011\|12654719)
GO:0005515	protein binding	Molecular Function	IEA (12520011\|12654719)
GO:0005525	GTP binding	Molecular Function	IEA (12520011\|12654719)
GO:0040017	positive regulation of locomotion	Biological Process	IMP (12529635)
GO:0040012	regulation of locomotion	Biological Process	IMP (9334382)
GO:0015031	protein transport	Biological Process	IEA (12520011\|12654719)
GO:0007617	mating behavior	Biological Process	IMP (9334382)
GO:0007271	synaptic transmission, cholinergic	Biological Process	IMP (9334382)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA (12520011\|12654719)
GO:0007165	signal transduction	Biological Process	IEA (12520011\|12654719)
GO:0006935	chemotaxis	Biological Process	IMP (9334382)
GO:0006913	nucleocytoplasmic transport	Biological Process	IEA (12520011\|12654719)
GO:0006886	intracellular protein transport	Biological Process	IEA (12520011\|12654719)
GO:0043051	regulation of pharyngeal pumping	Biological Process	IMP (9334382)