ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

DLST

Full Name:

dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)

Alias:

DLTS

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q24.3

Physical Location:

74418371-74440198 on NC_000014.7

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID	No. of Publications	Phenotype
DLST	1	Alcohol Amnestic Disorder
DLST	1	Alcohol-Induced Disorders
DLST	1	Alcohol-Induced Disorders Nervous System
DLST	1	Alcoholism
DLST	1	Alcohol-Related Disorders

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001933.3	NP_001924.2	NC_000014.7 range: 74418371..74440198

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045252	oxoglutarate dehydrogenase complex	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005759	mitochondrial matrix	Cellular Component	EXP (2188967)
GO:0031405	lipoic acid binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008415	acyltransferase activity	Molecular Function	IEA
GO:0004149	dihydrolipoyllysine-residue succinyltransferase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17220478)
GO:0008152	metabolic process	Biological Process	IEA
GO:0006091	generation of precursor metabolites and energy	Biological Process	TAS (8009371)
GO:0006099	tricarboxylic acid cycle	Biological Process	IEA