Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:175691
Symbol:alh-1
Organism:Caenorhabditis elegans (Worm)
Chromosome:III
Physical Location:5077723-5080625 on NC_003281.7
Gene Type:protein-coding
Human Ortholog:GeneID: 217    Symbol (Name): ALDH2 (aldehyde dehydrogenase 2 family (mitochondrial))
Ortholog Status:The human GeneID 217 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:F54D8.3
Note:Class IV: late repression
Dataset Information
Name:15028283
Method:Microarray
Phenotype:Ethanol response
Publication:Kwon et al. Genomics. (2004) Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. PubMed
Summary:We used in this report the nematode Caenorhabditis elegans as a model system to identify and characterize the genes that are affected by ethanol exposure and to link those genes functionally into an ethanol-induced gene network. By analyzing the expression profiles of all C. elegans ORFs using microarrays, we identified 230 genes affected by ethanol. While the ethanol response of some of the identified genes was significant at early time points, that of the majority was at late time points, indicating that the genes in the latter case might represent the physiological consequence of the ethanol exposure. We further characterized the early response genes that may represent those involved directly in the ethanol response. These genes included many heat shock protein genes, indicating that high concentration of ethanol acts as a strong stress to the animal.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_065680.4NP_498081.2NC_003281.7 range: 5077723..5080625
NM_181921.2NP_871650.1NC_003281.7 range: 5077723..5080625
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016491oxidoreductase activityMolecular FunctionIEA (12520011|12654719)
GO:0008152metabolic processBiological ProcessIEA (12520011|12654719)
Other Database Cross Links
NCBI Entrez Gene:175691
WormBase:WBGene00000107