ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CYTB

Full Name:

cytochrome b, mitochondrial

Organism:

Mus musculus (Mouse)

Chromosome:

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4519 Symbol (Name): CYTB (mitochondrially encoded cytochrome b)

Ortholog Status:

The human GeneID 4519 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cytb
Fold Change:		1.36
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	IDA (8030757)
GO:0005739	mitochondrion	Cellular Component	IDA (16120479)
GO:0005746	mitochondrial respiratory chain	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (16141072)
GO:0016020	membrane	Cellular Component	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	RCA (16141072)
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0008121	ubiquinol-cytochrome-c reductase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0022904	respiratory electron transport chain	Biological Process	IEA