ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

17874

Symbol:

Myd88

Full Name:

myeloid differentiation primary response gene 88

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 F3|9 70.0 cM

Physical Location:

119245105-119249157 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4615 Symbol (Name): MYD88 (myeloid differentiation primary response gene (88))

Ortholog Status:

The human GeneID 4615 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Etact2	Alcohol Stimulated Activity	9	61	51-71 (cM)	3.6	4.30E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010851.2	NP_034981.1	NC_000075.5 range: 119245105..119249157, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031224	intrinsic to membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	TAS (10465784)
GO:0004888	transmembrane receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10854325)
GO:0032496	response to lipopolysaccharide	Biological Process	IMP (12719478\|12855817\|12872135)
GO:0032760	positive regulation of tumor necrosis factor production	Biological Process	IGI (12872135)
GO:0032760	positive regulation of tumor necrosis factor production	Biological Process	IMP (12719478\|12872135)
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IGI (12855817)
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IMP (12855817)
GO:0045080	positive regulation of chemokine biosynthetic process	Biological Process	IGI (12855817)
GO:0045087	innate immune response	Biological Process	IEA
GO:0045351	type I interferon biosynthetic process	Biological Process	IMP (15800576)
GO:0046330	positive regulation of JNK cascade	Biological Process	IMP (12855817)
GO:0051092	activation of NF-kappaB transcription factor	Biological Process	IGI (12855817)
GO:0032496	response to lipopolysaccharide	Biological Process	IGI (12872135)
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	IMP (12855817)
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Biological Process	IGI (12719478)
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Biological Process	IMP (12872135)
GO:0006954	inflammatory response	Biological Process	IEA
GO:0006955	immune response	Biological Process	TAS (11526399)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007166	cell surface receptor linked signal transduction	Biological Process	IMP (12719478)
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	Biological Process	TAS (10465784)
GO:0009615	response to virus	Biological Process	IMP (14993594\|15800576)
GO:0016064	immunoglobulin mediated immune response	Biological Process	IMP (15800576)
GO:0002238	response to molecule of fungal origin	Biological Process	IMP (12719478)
GO:0051092	activation of NF-kappaB transcription factor	Biological Process	IMP (12855817)