ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nek2

Full Name:

NIMA (never in mitosis gene a)-related expressed kinase 2

Alias:

AA617254|C77054

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H6|1 103.0 cM

Physical Location:

193645440-193656920 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4751 Symbol (Name): NEK2 (NIMA (never in mitosis gene a)-related kinase 2)

Ortholog Status:

The human GeneID 4751 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Nek2

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Calw1/Alcdp1	Chronic Alcohol Withdrawal	1	96	89-106.3 (cM)	7.6	2.00E-09	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010892.3	NP_035022.2	NC_000067.5 range: 193645440..193656920

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0030496	midbody	Cellular Component	IDA (15479717)
GO:0000775	chromosome, pericentric region	Cellular Component	IEA
GO:0000794	condensed nuclear chromosome	Cellular Component	IDA (15479717)
GO:0000922	spindle pole	Cellular Component	IDA (15479717)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17274640)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0007126	meiosis	Biological Process	IEA
GO:0007067	mitosis	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0000070	mitotic sister chromatid segregation	Biological Process	IMP (15479717)
GO:0051301	cell division	Biological Process	IEA