ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nefl

Full Name:

neurofilament, light polypeptide

Alias:

AI847934|CMT2E|NF-L|NF68|Nfl

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

14 D3

Physical Location:

68701940-68705801 on NC_000080.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4747 Symbol (Name): NEFL (neurofilament, light polypeptide 68kDa)

Ortholog Status:

The human GeneID 4747 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws5/Alcw7	Chronic Alcohol Withdrawal	14		24-48 (cM)	4.2	6.00E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010910.1	NP_035040.1	NC_000080.5 range: 68701940..68705801

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005882	intermediate filament	Cellular Component	IDA (2493000)
GO:0005883	neurofilament	Cellular Component	IDA (8821035\|10221457\|15242779)
GO:0030424	axon	Cellular Component	IDA (8821035)
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12403814\|15208636\|16236762)
GO:0000226	microtubule cytoskeleton organization and biogenesis	Biological Process	IMP (11487626)
GO:0048812	neurite morphogenesis	Biological Process	IMP (10884316)
GO:0050772	positive regulation of axonogenesis	Biological Process	IMP (7946341)
GO:0050885	neuromuscular process controlling balance	Biological Process	IMP (15884021)
GO:0060052	neurofilament cytoskeleton organization and biogenesis	Biological Process	IGI (10350642\|10461886\|11343650)
GO:0045110	intermediate filament bundle assembly	Biological Process	IGI (10461886)
GO:0045109	intermediate filament organization	Biological Process	IMP (2121744\|7946341)
GO:0043524	negative regulation of neuron apoptosis	Biological Process	IMP (7946341\|10884316)
GO:0040011	locomotion	Biological Process	IMP (15132161)
GO:0031133	regulation of axon diameter	Biological Process	IMP (9398473\|11343650)
GO:0014012	axon regeneration in the peripheral nervous system	Biological Process	IMP (9398473)
GO:0060052	neurofilament cytoskeleton organization and biogenesis	Biological Process	IMP (9398473\|11487626\|14561875\|15132161\|16920084)