ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

pdi-2

Organism:

Caenorhabditis elegans (Worm)

Chromosome:

Physical Location:

4524156-4526504 on NC_003284.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5034 Symbol (Name): P4HB (procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide)

Ortholog Status:

The human GeneID 5034 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		C07A12.4
Note:		Class II: late induction

Dataset Information

Name:		15028283
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Kwon et al. Genomics. (2004) Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. PubMed
Summary:		We used in this report the nematode Caenorhabditis elegans as a model system to identify and characterize the genes that are affected by ethanol exposure and to link those genes functionally into an ethanol-induced gene network. By analyzing the expression profiles of all C. elegans ORFs using microarrays, we identified 230 genes affected by ethanol. While the ethanol response of some of the identified genes was significant at early time points, that of the majority was at late time points, indicating that the genes in the latter case might represent the physiological consequence of the ethanol exposure. We further characterized the early response genes that may represent those involved directly in the ethanol response. These genes included many heat shock protein genes, indicating that high concentration of ethanol acts as a strong stress to the animal.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA (12520011\|12654719)
GO:0016853	isomerase activity	Molecular Function	IEA (12520011\|12654719)
GO:0002119	nematode larval development	Biological Process	IMP (14551910)
GO:0040017	positive regulation of locomotion	Biological Process	IMP (12529635)
GO:0040011	locomotion	Biological Process	IMP (12529635\|14551910)
GO:0040010	positive regulation of growth rate	Biological Process	IMP (17897480)
GO:0040007	growth	Biological Process	IMP (14551910)
GO:0010171	body morphogenesis	Biological Process	IMP (14551910)
GO:0009792	embryonic development ending in birth or egg hatching	Biological Process	IMP (12529635)
GO:0045454	cell redox homeostasis	Biological Process	IEA (12520011\|12654719)