ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nkx2-2

Full Name:

NK2 transcription factor related, locus 2 (Drosophila)

Alias:

Nkx-2.2|Nkx2.2|tinman

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 H|2 82.0 cM

Physical Location:

147003281-147012137 on NC_000068.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4821 Symbol (Name): NKX2-2 (NK2 homeobox 2)

Ortholog Status:

The human GeneID 4821 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U31566
Fold Change:		-1.5, -1.6, -1.7, -1
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (14573534\|16306355)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (14573534)
GO:0003700	transcription factor activity	Molecular Function	IDA (14573534)
GO:0048468	cell development	Biological Process	IMP (11526078)
GO:0045666	positive regulation of neuron differentiation	Biological Process	IDA (10830170)
GO:0045665	negative regulation of neuron differentiation	Biological Process	IDA (10830170)
GO:0045597	positive regulation of cell differentiation	Biological Process	IMP (14729487)
GO:0045595	regulation of cell differentiation	Biological Process	IMP (14970313)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (11526078)
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0031018	endocrine pancreas development	Biological Process	IMP (9584121)
GO:0021529	spinal cord oligodendrocyte cell differentiation	Biological Process	IMP (11526078)
GO:0014003	oligodendrocyte development	Biological Process	IMP (11526078)
GO:0007399	nervous system development	Biological Process	IDA (14573534)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (14573534)
GO:0048665	neuron fate specification	Biological Process	IGI (16339193)