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Gene Information
Gene ID:181551
Symbol:nhr-3
Organism:Caenorhabditis elegans (Worm)
Chromosome:X
Physical Location:14558423-14561346 on NC_003284.6
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:H01A20.1
Note:Class II: late induction
Dataset Information
Name:15028283
Method:Microarray
Phenotype:Ethanol response
Publication:Kwon et al. Genomics. (2004) Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. PubMed
Summary:We used in this report the nematode Caenorhabditis elegans as a model system to identify and characterize the genes that are affected by ethanol exposure and to link those genes functionally into an ethanol-induced gene network. By analyzing the expression profiles of all C. elegans ORFs using microarrays, we identified 230 genes affected by ethanol. While the ethanol response of some of the identified genes was significant at early time points, that of the majority was at late time points, indicating that the genes in the latter case might represent the physiological consequence of the ethanol exposure. We further characterized the early response genes that may represent those involved directly in the ethanol response. These genes included many heat shock protein genes, indicating that high concentration of ethanol acts as a strong stress to the animal.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_078022.3NP_510423.1NC_003284.6 range: 14558423..14561346
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA (12520011|12654719)
GO:0003677DNA bindingMolecular FunctionIEA (12520011|12654719)
GO:0003700transcription factor activityMolecular FunctionIEA (12520011|12654719)
GO:0003707steroid hormone receptor activityMolecular FunctionIEA (12520011|12654719)
GO:0004879ligand-dependent nuclear receptor activityMolecular FunctionIEA (12520011|12654719)
GO:0008270zinc ion bindingMolecular FunctionIEA (12520011|12654719)
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA (12520011|12654719)
GO:0045449regulation of transcriptionBiological ProcessTAS (10022975)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA (12520011|12654719)
GO:0045471response to ethanolBiological ProcessIEP (15028283)
Other Database Cross Links
NCBI Entrez Gene:181551
WormBase:WBGene00003602