ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ddr2

Full Name:

discoidin domain receptor family, member 2

Alias:

AW495251|Ntrkr3|tyro10

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H1-H5|1 90.0 cM

Physical Location:

171907776-172040689 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4921 Symbol (Name): DDR2 (discoidin domain receptor tyrosine kinase 2)

Ortholog Status:

The human GeneID 4921 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Calw1/Alcdp1	Chronic Alcohol Withdrawal	1	96	89-106.3 (cM)	7.6	2.00E-09	Significant	PARC
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022563.2	NP_072075.2	NC_000067.5 range: 171907776..172040689, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (16141072)
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	IDA (11723120)
GO:0008284	positive regulation of cell proliferation	Biological Process	IMP (11723120)
GO:0007155	cell adhesion	Biological Process	IEA