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Gene Information
Gene ID:18227
Full Name:nuclear receptor subfamily 4, group A, member 2
Organism:Mus musculus (Mouse)
Genetic Location:2 C1.1|2 34.5 cM
Physical Location:56960566-56967665 on NC_000068.6, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4929    Symbol (Name): NR4A2 (nuclear receptor subfamily 4, group A, member 2)
Ortholog Status:The human GeneID 4929 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Nr4a2
Fold Change:5.87
P Value:0.001
Note:acute functional tolerance
Dataset Information
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Alcohol preference, acute functional tolerance
Publication:Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Alcp1Alcohol Preference Drinking22819-35 (cM)5.3 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013613.1NP_038641.1NC_000068.6 range: 56960566..56967665, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (11749040)
GO:0003677DNA bindingMolecular FunctionIDA (14671317)
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (14671317)
GO:0004879ligand-dependent nuclear receptor activityMolecular FunctionTAS (9092472)
GO:0004872receptor activityMolecular FunctionIEA
GO:0003707steroid hormone receptor activityMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIGI (15155786)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (14671317|15155786)
GO:0042053regulation of dopamine metabolic processBiological ProcessIDA (12915123)
GO:0030182neuron differentiationBiological ProcessIMP (9520484|14622207)
GO:0007399nervous system developmentBiological ProcessIMP (9092472|11749040)
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:18227