ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nr4a2

Full Name:

nuclear receptor subfamily 4, group A, member 2

Alias:

HZF-3|NOT|Nurr1|RNR-1|TINOR|TINUR

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 C1.1|2 34.5 cM

Physical Location:

56960566-56967665 on NC_000068.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4929 Symbol (Name): NR4A2 (nuclear receptor subfamily 4, group A, member 2)

Ortholog Status:

The human GeneID 4929 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		16783646
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Alcohol preference, acute functional tolerance
Publication:		Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:		Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcp1	Alcohol Preference Drinking	2	28	19-35 (cM)	5.3		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013613.1	NP_038641.1	NC_000068.6 range: 56960566..56967665, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (11749040)
GO:0003677	DNA binding	Molecular Function	IDA (14671317)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (14671317)
GO:0004879	ligand-dependent nuclear receptor activity	Molecular Function	TAS (9092472)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0003707	steroid hormone receptor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15155786)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (14671317\|15155786)
GO:0042053	regulation of dopamine metabolic process	Biological Process	IDA (12915123)
GO:0030182	neuron differentiation	Biological Process	IMP (9520484\|14622207)
GO:0007399	nervous system development	Biological Process	IMP (9092472\|11749040)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA