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Gene Information
Gene ID:1832
Symbol:DSP
Full Name:desmoplakin
Alias:DPI|DPII
Organism:Homo sapiens (Human)
Chromosome:6
Genetic Location:6p24
Physical Location:7486868-7531944 on NC_000006.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:DSP
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D6S1574  5957132
Region:3957132-7957132
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
MarkerLODP valueLocation (bp)
D6S309  8169921
Region:6169921-10169921
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001008844.1NP_001008844.1NC_000006.10 range: 7486868..7531944
NM_004415.2NP_004406.2NC_000006.10 range: 7486868..7531944
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0001533cornified envelopeCellular ComponentIDA (10908733)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005882intermediate filamentCellular ComponentNR
GO:0005913cell-cell adherens junctionCellular ComponentNR
GO:0005200structural constituent of cytoskeletonMolecular FunctionTAS (9887343)
GO:0030674protein binding, bridgingMolecular FunctionIDA (10908733)
GO:0008544epidermis developmentBiological ProcessTAS (9887343)
GO:0018149peptide cross-linkingBiological ProcessIDA (10908733)
GO:0030216keratinocyte differentiationBiological ProcessIDA (10908733)
Other Database Cross Links
NCBI Entrez Gene:1832
HGNC:3052
Ensembl:ENSG00000096696
MIM:125647
HPRD:00513
HuGE Navigator:1832
dbSNP:DSP
GeneCard:DSP
AceView:DSP