ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

18436

Symbol:

P2rx1

Full Name:

purinergic receptor P2X, ligand-gated ion channel, 1

Alias:

AI323649|BB122383|P2x|Pdcd3|RP-2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B4|11 40.0 cM

Physical Location:

72812648-72828700 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5023 Symbol (Name): P2RX1 (purinergic receptor P2X, ligand-gated ion channel, 1)

Ortholog Status:

The human GeneID 5023 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore4	Alcohol-induced Loss of Righting Reflex	11		36-42 (cM)	6.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008771.3	NP_032797.3	NC_000077.5 range: 72812648..72828700

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0031240	external side of cell outer membrane	Cellular Component	IDA (11570704)
GO:0045211	postsynaptic membrane	Cellular Component	IDA (11668586)
GO:0001614	purinergic nucleotide receptor activity	Molecular Function	IMP (10638758)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005261	cation channel activity	Molecular Function	ISO
GO:0005261	cation channel activity	Molecular Function	IMP (10638758)
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0001614	purinergic nucleotide receptor activity	Molecular Function	ISO
GO:0016265	death	Biological Process	IMP (12913094)
GO:0019229	regulation of vasoconstriction	Biological Process	IMP (14679185)
GO:0030168	platelet activation	Biological Process	IMP (12913094)
GO:0050896	response to stimulus	Biological Process	IMP (14679185)
GO:0033198	response to ATP	Biological Process	IMP (14722245)
GO:0043270	positive regulation of ion transport	Biological Process	IGI (15914557)
GO:0043270	positive regulation of ion transport	Biological Process	IMP (15914557)
GO:0010033	response to organic substance	Biological Process	IMP (15914557)
GO:0002554	serotonin secretion by platelet	Biological Process	IMP (12913094)
GO:0003056	regulation of vascular smooth muscle contraction	Biological Process	IMP (16920810)
GO:0006810	transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IMP (10638758)
GO:0006811	ion transport	Biological Process	ISO
GO:0006915	apoptosis	Biological Process	IEA
GO:0006940	regulation of smooth muscle contraction	Biological Process	IMP (10638758\|11570704)
GO:0007320	insemination	Biological Process	IMP (10638758)
GO:0051924	regulation of calcium ion transport	Biological Process	IMP (16920810)