ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

18505

Symbol:

Pax3

Full Name:

paired box gene 3

Alias:

Pax-3|Sp|splotch

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 C4|1 44.0 cM

Physical Location:

78099266-78193710 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5077 Symbol (Name): PAX3 (paired box 3)

Ortholog Status:

The human GeneID 5077 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws1/Alcw5	Chronic Alcohol Withdrawal	1		28-47 (cM)	6.5	3.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008781.3	NP_032807.2	NC_000067.5 range: 78099266..78193710, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005667	transcription factor complex	Cellular Component	TAS (10197584)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (9464541\|17662948)
GO:0016566	specific transcriptional repressor activity	Molecular Function	IDA (15729346)
GO:0003705	RNA polymerase II transcription factor activity, enhancer binding	Molecular Function	IGI (15729346)
GO:0003705	RNA polymerase II transcription factor activity, enhancer binding	Molecular Function	IDA (15729346)
GO:0003700	transcription factor activity	Molecular Function	TAS (10197584)
GO:0003682	chromatin binding	Molecular Function	IDA (15729346)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016563	transcription activator activity	Molecular Function	IDA (15729346\|16300735)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0016477	cell migration	Biological Process	IMP (15132998)
GO:0021915	neural tube development	Biological Process	IGI (10419687)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15729346)
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (15729346\|16300735)
GO:0009887	organ morphogenesis	Biological Process	TAS (10197584)
GO:0008284	positive regulation of cell proliferation	Biological Process	IMP (10946068)
GO:0008283	cell proliferation	Biological Process	IMP (15132998)
GO:0007517	muscle development	Biological Process	IMP (15132998)
GO:0007507	heart development	Biological Process	IMP (10231856)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0001843	neural tube closure	Biological Process	IMP (15384171)
GO:0001755	neural crest cell migration	Biological Process	IMP (15384171)
GO:0048066	pigmentation during development	Biological Process	IMP (15322542)