ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

18514

Symbol:

Pbx1

Full Name:

pre B-cell leukemia transcription factor 1

Alias:

2310056B04Rik|AI848790|AU015730|D230003C07Rik|Pbx-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H2.3|1 88.1 cM

Physical Location:

170049494-170362388 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5087 Symbol (Name): PBX1 (pre-B-cell leukemia homeobox 1)

Ortholog Status:

The human GeneID 5087 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008783.2	NP_032809.1	NC_000067.5 range: 170049494..170362388, complement
NM_183355.2	NP_899198.1	NC_000067.5 range: 170049494..170362388, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005667	transcription factor complex	Cellular Component	IDA (17049510)
GO:0005737	cytoplasm	Cellular Component	IDA (12724421\|15087118)
GO:0005634	nucleus	Cellular Component	IDA (9315626\|11010815\|11566859\|11912494\|12724421\|15087118\|15581866)
GO:0043565	sequence-specific DNA binding	Molecular Function	IGI (17049510)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (15634706\|16847320\|17178831)
GO:0046982	protein heterodimerization activity	Molecular Function	IPI (15944191)
GO:0005515	protein binding	Molecular Function	IPI (9315626)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IDA (9315626\|15944191)
GO:0042127	regulation of cell proliferation	Biological Process	IMP (11566859)
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0001655	urogenital system development	Biological Process	IMP (14595835)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (15944191)
GO:0048536	spleen development	Biological Process	IGI (15944191)
GO:0048536	spleen development	Biological Process	IMP (15944191)
GO:0048538	thymus development	Biological Process	IMP (15581866)
GO:0048568	embryonic organ development	Biological Process	IMP (15581866)
GO:0030325	adrenal gland development	Biological Process	IMP (14595835)
GO:0030278	regulation of ossification	Biological Process	IMP (11566859)
GO:0001658	ureteric bud branching	Biological Process	IDA (12591246)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006700	C21-steroid hormone biosynthetic process	Biological Process	IEA
GO:0007530	sex determination	Biological Process	IEA
GO:0008284	positive regulation of cell proliferation	Biological Process	IMP (15944191)
GO:0009887	organ morphogenesis	Biological Process	IMP (11912494)
GO:0009952	anterior/posterior pattern formation	Biological Process	IMP (11566859)
GO:0009954	proximal/distal pattern formation	Biological Process	IMP (11566859)
GO:0030154	cell differentiation	Biological Process	IEA
GO:0048706	embryonic skeletal development	Biological Process	IMP (11566859)