Gene Information |
Gene ID: | | 18643 |
Symbol: | | Pfn1 |
Full Name: | | profilin 1 |
Alias: | | Pfn |
Organism: | | Mus musculus (Mouse) |
Chromosome: | | 11 |
Genetic Location: | | 11 B4|11 42.0 cM |
Physical Location: | | 70465350-70468136 on NC_000077.5, complement |
Gene Type: | | protein-coding |
Human Ortholog: | | GeneID: 5216 Symbol (Name): PFN1 (profilin 1) |
Ortholog Status: | | The human GeneID 5216 is also in human dataset(s). |
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Gene in Ethanol Study Datasets |
Gene Information | Original ID1: | | Pfn1 | Fold Change: | | 8.21 | P Value: | | 0 | Note: | | acute functional tolerance |
| Dataset Information | Name: | | 16783646 | Method: | | Microarray and QTL | Tissue: | | Whole brain | Phenotype: | | Alcohol preference, acute functional tolerance | Publication: | | Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed | Summary: | | Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance |
| Gene Information | Original ID1: | | Pfn1 | Fold Change: | | 1.41 | Note: | | Significantly regulated by ethanol in cortical neurons |
| Gene Information | Original ID1: | | Pfn1 | Fold Change: | | 1.35 | Note: | | Significantly regulated in cortical neurons treated with both ethanol and nicotine |
| Dataset Information | Name: | | 17295719 | Method: | | Microarray | Tissue: | | Cultured fetal mouse cortical neurons | Phenotype: | | Ethanol response | Publication: | | Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed | Summary: | | By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test. |
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QTL Information | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
Lore4 | Alcohol-induced Loss of Righting Reflex | 11 | | 36-42 (cM) | 6.5 | | Significant | PARC |
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Gene Refseq Sequence Annotation |
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Gene Ontology (GO) Annotation |
GO ID | GO Term | Category | Evidence (PubMed) | |
GO:0005634 | nucleus | Cellular Component | IDA (15615774) | |
GO:0005737 | cytoplasm | Cellular Component | IDA (11274401) | |
GO:0005856 | cytoskeleton | Cellular Component | RCA (12466851) | |
GO:0015629 | actin cytoskeleton | Cellular Component | RCA (12466851) | |
GO:0003779 | actin binding | Molecular Function | RCA (12466851) | |
GO:0005515 | protein binding | Molecular Function | IPI (11826110|15615774) | |
GO:0001843 | neural tube closure | Biological Process | IGI (10069337) | |
GO:0030036 | actin cytoskeleton organization and biogenesis | Biological Process | IEA | |
GO:0008064 | regulation of actin polymerization and/or depolymerization | Biological Process | TAS (11274401) | |
GO:0007010 | cytoskeleton organization and biogenesis | Biological Process | RCA (12466851) | |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | Biological Process | IGI (15615774) | |
GO:0042989 | sequestering of actin monomers | Biological Process | TAS (11274401) | |
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Other Database Cross Links |
NCBI Entrez Gene: | | 18643 |
MGI: | |
Ensembl: | | ENSMUSG00000018293 |
dbSNP: | | Pfn1 |
AceView: | | Pfn1 |