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Gene Information
Gene ID:18643
Full Name:profilin 1
Organism:Mus musculus (Mouse)
Genetic Location:11 B4|11 42.0 cM
Physical Location:70465350-70468136 on NC_000077.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5216    Symbol (Name): PFN1 (profilin 1)
Ortholog Status:The human GeneID 5216 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pfn1
Fold Change:8.21
P Value:0
Note:acute functional tolerance
Dataset Information
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Alcohol preference, acute functional tolerance
Publication:Saba et al. Mamm Genome. (2006) Candidate genes and their regulatory elements: alcohol preference and tolerance. PubMed
Summary:Identified of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance
Gene Information
Original ID1:Pfn1
Fold Change:1.41
Note:Significantly regulated by ethanol in cortical neurons
Gene Information
Original ID1:Pfn1
Fold Change:1.35
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Lore4Alcohol-induced Loss of Righting Reflex11 36-42 (cM)6.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011072.3NP_035202.1NC_000077.5 range: 70465350..70468136, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (15615774)
GO:0005737cytoplasmCellular ComponentIDA (11274401)
GO:0005856cytoskeletonCellular ComponentRCA (12466851)
GO:0015629actin cytoskeletonCellular ComponentRCA (12466851)
GO:0003779actin bindingMolecular FunctionRCA (12466851)
GO:0005515protein bindingMolecular FunctionIPI (11826110|15615774)
GO:0001843neural tube closureBiological ProcessIGI (10069337)
GO:0030036actin cytoskeleton organization and biogenesisBiological ProcessIEA
GO:0008064regulation of actin polymerization and/or depolymerizationBiological ProcessTAS (11274401)
GO:0007010cytoskeleton organization and biogenesisBiological ProcessRCA (12466851)
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessIGI (15615774)
GO:0042989sequestering of actin monomersBiological ProcessTAS (11274401)
Other Database Cross Links
NCBI Entrez Gene:18643