| Gene Information |
| Gene ID: | | 18746 |
| Symbol: | | Pkm2 |
| Full Name: | | pyruvate kinase, muscle |
| Alias: | | AA414905|AL024370|AL024424|Pk-2|Pk-3|Pk3 |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 9 |
| Genetic Location: | | 9 B|9 52.0 cM |
| Physical Location: | | 59504414-59527181 on NC_000075.5 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 5315 Symbol (Name): PKM2 (pyruvate kinase, muscle) |
| Ortholog Status: | | The human GeneID 5315 is not in current human dataset. |
|
| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Pk3 | | Fold Change: | | 0.63 | | Note: | | Significantly regulated by ethanol in cortical neurons |
| | Gene Information | | Original ID1: | | Pk3 | | Fold Change: | | 0.6 | | Note: | | Significantly regulated in cortical neurons treated with both ethanol and nicotine |
| | Dataset Information | | Name: | | 17295719 | | Method: | | Microarray | | Tissue: | | Cultured fetal mouse cortical neurons | | Phenotype: | | Ethanol response | | Publication: | | Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed | | Summary: | | By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test. |
|
|
| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Etact2 | Alcohol Stimulated Activity | 9 | 61 | 51-71 (cM) | 3.6 | 4.30E-05 | Significant | PARC |
|
|
| Gene Refseq Sequence Annotation |
|
| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005739 | mitochondrion | Cellular Component | IDA (14651853) | |
| GO:0000287 | magnesium ion binding | Molecular Function | IEA | |
| GO:0030955 | potassium ion binding | Molecular Function | IEA | |
| GO:0016740 | transferase activity | Molecular Function | IEA | |
| GO:0016301 | kinase activity | Molecular Function | IEA | |
| GO:0046872 | metal ion binding | Molecular Function | IEA | |
| GO:0005515 | protein binding | Molecular Function | IPI (18191611) | |
| GO:0004743 | pyruvate kinase activity | Molecular Function | IDA (7262549|7295297) | |
| GO:0003824 | catalytic activity | Molecular Function | IEA | |
| GO:0006096 | glycolysis | Biological Process | IDA (7262549|7295297) | |
|
| Other Database Cross Links |
| NCBI Entrez Gene: | | 18746 |
| MGI: | |
| Ensembl: | | ENSMUSG00000032294 |
| dbSNP: | | Pkm2 |
| AceView: | | Pkm2 |
