ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Plcb1

Full Name:

phospholipase C, beta 1

Alias:

3110043I21Rik|AI132408|Plcb|mKIAA0581

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 F3|2 76.7 cM

Physical Location:

134612265-135298157 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23236 Symbol (Name): PLCB1 (phospholipase C, beta 1 (phosphoinositide-specific))

Ortholog Status:

The human GeneID 23236 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Plcb1
Fold Change:		1.3
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore2	Alcohol-induced Loss of Righting Reflex	2		75.6-81.7 (cM)	6.6		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019677.1	NP_062651.1	NC_000068.6 range: 134612265..135298157

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS (15702972)
GO:0004435	phosphoinositide phospholipase C activity	Molecular Function	RCA (16141072)
GO:0016787	hydrolase activity	Molecular Function	RCA (16141072)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	RCA (16141072)
GO:0004629	phospholipase C activity	Molecular Function	RCA (16141072)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0016042	lipid catabolic process	Biological Process	RCA (16141072)
GO:0006629	lipid metabolic process	Biological Process	IEA