ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Plcg1

Full Name:

phospholipase C, gamma 1

Alias:

AI894140|Cded|Plc-1|Plc-gamma1|Plcg-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 H2|2 92.0 cM

Physical Location:

160557045-160601495 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5335 Symbol (Name): PLCG1 (phospholipase C, gamma 1)

Ortholog Status:

The human GeneID 5335 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Plcg1
Fold Change:		1.33
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021280.3	NP_067255.2	NC_000068.6 range: 160557045..160601495

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS (15702972)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0035254	glutamate receptor binding	Molecular Function	IPI (16710293)
GO:0005515	protein binding	Molecular Function	IPI (10373493\|15953601)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0004629	phospholipase C activity	Molecular Function	IEA
GO:0004435	phosphoinositide phospholipase C activity	Molecular Function	IEA
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0016042	lipid catabolic process	Biological Process	IEA
GO:0001701	in utero embryonic development	Biological Process	IMP (11744703)