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Gene Information
Gene ID:19043
Symbol:Ppm1b
Full Name:protein phosphatase 1B, magnesium dependent, beta isoform
Alias:MGC106489|PP2CB
Organism:Mus musculus (Mouse)
Chromosome:17
Genetic Location:17 E4-E5|17 50.8 cM
Physical Location:85357354-85416460 on NC_000083.5
Gene Type:protein-coding
Human Ortholog:GeneID: 5495    Symbol (Name): PPM1B (protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform)
Ortholog Status:The human GeneID 5495 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:D45859
Fold Change:1.6, 1.7, NC, 1.3
Note:4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2
Dataset Information
Name:15002731
Method:Microarray
Tissue:Whole brain
Phenotype:Acute ethanol response
Publication:Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011151.1NP_035281.1NC_000083.5 range: 85357354..85416460
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0008287protein serine/threonine phosphatase complexCellular ComponentIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0003824catalytic activityMolecular FunctionIEA
GO:0004721phosphoprotein phosphatase activityMolecular FunctionIEA
GO:0004722protein serine/threonine phosphatase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0030145manganese ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:19043
MGI:
Ensembl:ENSMUSG00000061130
dbSNP:Ppm1b
AceView:Ppm1b