ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ppm1b

Full Name:

protein phosphatase 1B, magnesium dependent, beta isoform

Alias:

MGC106489|PP2CB

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 E4-E5|17 50.8 cM

Physical Location:

85357354-85416460 on NC_000083.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5495 Symbol (Name): PPM1B (protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform)

Ortholog Status:

The human GeneID 5495 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D45859
Fold Change:		1.6, 1.7, NC, 1.3
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011151.1	NP_035281.1	NC_000083.5 range: 85357354..85416460

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008287	protein serine/threonine phosphatase complex	Cellular Component	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	IEA
GO:0004722	protein serine/threonine phosphatase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA