ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ppp1cb

Full Name:

protein phosphatase 1, catalytic subunit, beta isoform

Alias:

1200010B19

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 B1

Physical Location:

32761632-32795126 on NC_000071.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5500 Symbol (Name): PPP1CB (protein phosphatase 1, catalytic subunit, beta isoform)

Ortholog Status:

The human GeneID 5500 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ppp1cb
Fold Change:		1.4
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_172707.3	NP_766295.2	NC_000071.5 range: 32761632..32795126

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	IEA
GO:0004722	protein serine/threonine phosphatase activity	Molecular Function	IDA (14640981)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17274640)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	RCA (16141072)
GO:0000910	cytokinesis	Biological Process	RCA (16141072)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IDA (14640981)
GO:0005977	glycogen metabolic process	Biological Process	RCA (16141072)
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0051301	cell division	Biological Process	IEA