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Gene Information
Gene ID:19055
Full Name:protein phosphatase 3, catalytic subunit, alpha isoform
Organism:Mus musculus (Mouse)
Genetic Location:3 G3
Physical Location:136333733-136598742 on NC_000069.5
Gene Type:protein-coding
Human Ortholog:GeneID: 5530    Symbol (Name): PPP3CA (protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform)
Ortholog Status:The human GeneID 5530 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Calna
Fold Change:1.73
Note:Significantly regulated by ethanol in cortical neurons
Gene Information
Original ID1:Calna
Fold Change:1.48
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008913.4NP_032939.1NC_000069.5 range: 136333733..136598742
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030018Z discCellular ComponentIDA (15665106)
GO:0005955calcineurin complexCellular ComponentIDA (12617961)
GO:0005829cytosolCellular ComponentIDA (12617961)
GO:0005792microsomeCellular ComponentIDA (12617961)
GO:0005739mitochondrionCellular ComponentIDA (12617961)
GO:0005634nucleusCellular ComponentIDA (12617961)
GO:0005516calmodulin bindingMolecular FunctionRCA (12466851)
GO:0017018myosin phosphatase activityMolecular FunctionRCA (12466851)
GO:0016787hydrolase activityMolecular FunctionRCA (12466851)
GO:0030145manganese ion bindingMolecular FunctionRCA (12466851)
GO:0008420CTD phosphatase activityMolecular FunctionRCA (12466851)
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0004721phosphoprotein phosphatase activityMolecular FunctionIDA (16024798)
GO:0004722protein serine/threonine phosphatase activityMolecular FunctionRCA (12466851)
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (12574411|12617961|15665106|16717086)
GO:0048741skeletal muscle fiber developmentBiological ProcessIMP (16024798)
GO:0050804regulation of synaptic transmissionBiological ProcessIMP (15590926)
GO:0000082G1/S transition of mitotic cell cycleBiological ProcessIMP (12660151)
GO:0016311dephosphorylationBiological ProcessIDA (12574411|16024798)
GO:0006950response to stressBiological ProcessIDA (11782539)
GO:0006816calcium ion transportBiological ProcessIMP (12660151)
GO:0006606protein import into nucleusBiological ProcessIDA (11782539)
GO:0060079regulation of excitatory postsynaptic membrane potentialBiological ProcessIGI (17428973)
Other Database Cross Links
NCBI Entrez Gene:19055