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Gene Information
Gene ID:19158
Symbol:Pscd2
Full Name:pleckstrin homology, Sec7 and coiled-coil domains 2
Alias:CLM2
Organism:Mus musculus (Mouse)
Chromosome:7
Genetic Location:7 B4
Physical Location:53062006-53069655 on NC_000073.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9266    Symbol (Name): PSCD2 (pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2))
Ortholog Status:The human GeneID 9266 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pscd2
Fold Change:0.79
Note:Significantly regulated by ethanol in cortical neurons
Gene Information
Original ID1:Pscd2
Fold Change:0.8
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011181.3NP_035311.1NC_000073.5 range: 53062006..53069655, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISO
GO:0005886plasma membraneCellular ComponentISO
GO:0005085guanyl-nucleotide exchange factor activityMolecular FunctionRCA (12466851)
GO:0005086ARF guanyl-nucleotide exchange factor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (16415858)
GO:0030155regulation of cell adhesionBiological ProcessISO
GO:0032012regulation of ARF protein signal transductionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:19158
MGI:
Ensembl:ENSMUSG00000003269
dbSNP:Pscd2
AceView:Pscd2