ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

19165

Symbol:

Psen2

Full Name:

presenilin 2

Alias:

AI266870|ALG-3|Ad4h|PS-2|PS2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H4|1 101.0 cM

Physical Location:

182157136-182176031 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5664 Symbol (Name): PSEN2 (presenilin 2 (Alzheimer disease 4))

Ortholog Status:

The human GeneID 5664 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Calw1/Alcdp1	Chronic Alcohol Withdrawal	1	96	89-106.3 (cM)	7.6	2.00E-09	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011183.2	NP_035313.2	NC_000067.5 range: 182157136..182176031, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	IDA (9535056)
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	TAS (10854253)
GO:0005624	membrane fraction	Cellular Component	IDA (9535056\|12684521\|15474363\|15886206)
GO:0016020	membrane	Cellular Component	IEA
GO:0043025	cell soma	Cellular Component	IDA (9203550)
GO:0030018	Z disc	Cellular Component	IDA (16204356)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11719200\|15474363\|16204356)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0004175	endopeptidase activity	Molecular Function	IMP (12684521\|17556541)
GO:0040011	locomotion	Biological Process	IGI (15148382)
GO:0043065	positive regulation of apoptosis	Biological Process	IGI (16169548)
GO:0043066	negative regulation of apoptosis	Biological Process	IDA (9353287)
GO:0043066	negative regulation of apoptosis	Biological Process	IGI (9353287)
GO:0042640	anagen	Biological Process	IGI (15525534)
GO:0044267	cellular protein metabolic process	Biological Process	IGI (17097608)
GO:0048167	regulation of synaptic plasticity	Biological Process	IGI (15066262)
GO:0060048	cardiac muscle contraction	Biological Process	IMP (16204356)
GO:0051605	protein maturation via proteolysis	Biological Process	IGI (15280425)
GO:0051604	protein maturation	Biological Process	IGI (11943765)
GO:0050852	T cell receptor signaling pathway	Biological Process	IGI (17698590)
GO:0050820	positive regulation of coagulation	Biological Process	IMP (12646573)
GO:0050435	beta-amyloid metabolic process	Biological Process	IMP (12684521)
GO:0050435	beta-amyloid metabolic process	Biological Process	IDA (10846187)
GO:0048854	brain morphogenesis	Biological Process	IGI (17614943)
GO:0048538	thymus development	Biological Process	IGI (17698590)
GO:0048286	alveolus development	Biological Process	IMP (10518543)
GO:0030900	forebrain development	Biological Process	IGI (15148382)
GO:0030326	embryonic limb morphogenesis	Biological Process	IGI (16169548)
GO:0001933	negative regulation of protein amino acid phosphorylation	Biological Process	IGI (15148382)
GO:0001942	hair follicle development	Biological Process	IGI (10557208)
GO:0002244	hemopoietic progenitor cell differentiation	Biological Process	IGI (15122901)
GO:0002286	T cell activation during immune response	Biological Process	IGI (17698590)
GO:0002573	myeloid leukocyte differentiation	Biological Process	IGI (15122901)
GO:0001708	cell fate specification	Biological Process	IGI (15525534)
GO:0006816	calcium ion transport	Biological Process	IPI (16204356)
GO:0006915	apoptosis	Biological Process	IDA (8940094\|9353287)
GO:0006915	apoptosis	Biological Process	IGI (15148382)
GO:0007176	regulation of epidermal growth factor receptor activity	Biological Process	IGI (17556541)
GO:0007219	Notch signaling pathway	Biological Process	IGI (17698590)
GO:0007611	learning and/or memory	Biological Process	IGI (15066262)
GO:0007613	memory	Biological Process	IGI (15148382\|17614943)
GO:0009790	embryonic development	Biological Process	IGI (10518543\|10557208)
GO:0015031	protein transport	Biological Process	IGI (11943765)
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0021904	dorsoventral neural tube patterning	Biological Process	IGI (10557208)
GO:0001756	somitogenesis	Biological Process	IGI (10557208)