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Gene Information
Gene ID:19172
Full Name:proteasome (prosome, macropain) subunit, beta type 4
Organism:Mus musculus (Mouse)
Genetic Location:3 F2|3 43.1 cM
Physical Location:94688245-94690853 on NC_000069.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5692    Symbol (Name): PSMB4 (proteasome (prosome, macropain) subunit, beta type, 4)
Ortholog Status:The human GeneID 5692 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Psmb4
Fold Change:1.41
Note:Significantly regulated by ethanol in cortical neurons
Gene Information
Original ID1:Psmb4
Fold Change:1.3
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008945.2NP_032971.1NC_000069.5 range: 94688245..94690853, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005829cytosolCellular ComponentIEA
GO:0005839proteasome core complexCellular ComponentIEA
GO:0043234protein complexCellular ComponentIEA
GO:0004298threonine endopeptidase activityMolecular FunctionIEA
GO:0008233peptidase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:19172