ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ptp4a2

Full Name:

protein tyrosine phosphatase 4a2

Alias:

MGC102154|MGC103400|Prl-2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 D2.3

Physical Location:

129516716-129527218 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8073 Symbol (Name): PTP4A2 (protein tyrosine phosphatase type IVA, member 2)

Ortholog Status:

The human GeneID 8073 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ptp4a2
Fold Change:		1.54
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008974.3	NP_033000.1	NC_000070.5 range: 129516716..129527218

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005768	endosome	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	IEA
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA
GO:0016311	dephosphorylation	Biological Process	IEA