ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

19264

Symbol:

Ptprc

Full Name:

protein tyrosine phosphatase, receptor type, C

Alias:

B220|CD45R|Cd45|Ly-5|Lyt-4|T200|loc

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 E4|1 74.0 cM

Physical Location:

139959991-140071842 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5788 Symbol (Name): PTPRC (protein tyrosine phosphatase, receptor type, C)

Ortholog Status:

The human GeneID 5788 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011210.3	NP_035340.2	NC_000067.5 range: 139959991..140071842, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0009897	external side of plasma membrane	Cellular Component	IDA (61878\|6610701\|7477352\|7477353\|7589135\|7630421\|7688139\|7751624\|8041705\|8043862\|8552190\|8566025\|866692)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0005925	focal adhesion	Cellular Component	IDA (9197241)
GO:0008201	heparin binding	Molecular Function	IDA (8043862)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IDA (7743522\|8566025)
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	IEA
GO:0019901	protein kinase binding	Molecular Function	IPI (11201744)
GO:0043395	heparan sulfate proteoglycan binding	Molecular Function	IDA (8043862)
GO:0005515	protein binding	Molecular Function	IPI (9148925)
GO:0045577	regulation of B cell differentiation	Biological Process	IMP (8666928\|9254656)
GO:0045060	negative thymic T cell selection	Biological Process	IMP (8666928)
GO:0045582	positive regulation of T cell differentiation	Biological Process	IMP (8666928)
GO:0045059	positive thymic T cell selection	Biological Process	IMP (8666928)
GO:0043410	positive regulation of MAPKKK cascade	Biological Process	IMP (9254656)
GO:0045588	positive regulation of gamma-delta T cell differentiation	Biological Process	IMP (7807014)
GO:0051726	regulation of cell cycle	Biological Process	IDA (10970857)
GO:0051607	defense response to virus	Biological Process	IMP (8334701)
GO:0051209	release of sequestered calcium ion into cytosol	Biological Process	IDA (10508267)
GO:0050857	positive regulation of antigen receptor-mediated signaling pathway	Biological Process	IMP (8692271)
GO:0050855	regulation of B cell receptor signaling pathway	Biological Process	IMP (7499277)
GO:0050853	B cell receptor signaling pathway	Biological Process	IMP (9254656)
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Biological Process	IMP (7499277\|8175795)
GO:0048304	positive regulation of isotype switching to IgG isotypes	Biological Process	IMP (9015183)
GO:0046641	positive regulation of alpha-beta T cell proliferation	Biological Process	IMP (7751624)
GO:0043065	positive regulation of apoptosis	Biological Process	IMP (8666928)
GO:0042981	regulation of apoptosis	Biological Process	IMP (7743522)
GO:0001916	positive regulation of T cell mediated cytotoxicity	Biological Process	IMP (6233370)
GO:0001960	negative regulation of cytokine and chemokine mediated signaling pathway	Biological Process	IDA (11201744)
GO:0002711	positive regulation of T cell mediated immunity	Biological Process	IMP (6233370\|8566034)
GO:0002923	regulation of humoral immune response mediated by circulating immunoglobulin	Biological Process	IMP (9015183)
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	Biological Process	IMP (8566034)
GO:0000187	activation of MAPK activity	Biological Process	IMP (9254656)
GO:0006469	negative regulation of protein kinase activity	Biological Process	IDA (10970857)
GO:0006470	protein amino acid dephosphorylation	Biological Process	IDA (9197241)
GO:0007159	leukocyte adhesion	Biological Process	IMP (7743522)
GO:0016311	dephosphorylation	Biological Process	IEA
GO:0030183	B cell differentiation	Biological Process	IMP (12902479)
GO:0030890	positive regulation of B cell proliferation	Biological Process	IMP (8566034\|8666928\|9015183\|9254656)
GO:0031953	negative regulation of protein amino acid autophosphorylation	Biological Process	IMP (7499277\|8175795)
GO:0034113	heterotypic cell-cell adhesion	Biological Process	IMP (7743522)
GO:0042098	T cell proliferation	Biological Process	IMP (12902479)
GO:0001915	negative regulation of T cell mediated cytotoxicity	Biological Process	IMP (9725213)